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the gem is actually a radioactive 'utonium' of some sort, but you never find that out, and so you (and your friends/family?) die of apparently mysterious aggressive cancers and cellular degradation within 6 months or less.
You get a mysterious and interesting looking package in the mail.
only to realize that it was H2O2, and you deeply vomit All Night Long, spewing up all sorts of substances that you've never seen, nevermind don't have names for.
a hot girl in a van offers you a ride somewhere....
but its cursed by the Old Ones, so you become an epicly horrible insane gibbering reality warper, bringing about armageddon ala The Mist, except that it doesn't end.